If you're exploring GLP-1 medications for weight loss or metabolic support, you’ve likely come across three terms over and over again: Wegovy®, Ozempic®, and Compounded Semaglutide. They all promise similar outcomes—reduced appetite, better blood sugar control, and real weight loss—but the differences between them can be confusing, and potentially costly.

Let’s break down how these options compare, what the science says, and which one might be the right fit for you in 2025.

First, What Do They Have in Common?

All three options—Wegovy, Ozempic, and compounded semaglutide—are based on the GLP-1 receptor agonist semaglutide. This hormone:

• Slows digestion

• Reduces appetite

• Improves insulin sensitivity

• Helps regulate blood sugar and cravings

But how they’re made, dosed, and regulated? That’s where the differences begin.

Wegovy: FDA-Approved for Weight Loss

Wegovy® (semaglutide 2.4mg weekly) is the only FDA-approved semaglutide product specifically for weight loss. It’s manufactured by Novo Nordisk and clinically proven to help patients lose 15% or more of their body weight when combined with lifestyle changes.

Pros:

• High-dose formulation made specifically for obesity

• Covered by some insurance plans

• Robust clinical trial backing

Cons:

• Limited availability due to demand

• Expensive without insurance (up to $1,300/month)

• Insurance prior authorizations can be difficult

Ozempic: FDA-Approved for Diabetes—Used Off-Label for Weight Loss

Ozempic® (semaglutide up to 2.0mg weekly) is technically a type 2 diabetes medication, but it's widely prescribed off-label for weight loss because it uses the same molecule.

Pros:

• More available than Wegovy in many areas

• Insurance coverage is easier for those with diabetes

• Often leads to 10–15% weight loss even at lower doses

Cons:

• Lower dose than Wegovy, so may plateau earlier

• Side effects are still present

• Still costly without insurance (roughly $1,000/month)

Compounded Semaglutide: A More Affordable, Less Regulated Alternative

Compounded semaglutide is not an FDA-approved product, but it can be legally prepared by specialty pharmacies when brand-name drugs are in shortage—something the GLP-1 market has seen repeatedly.

Pros:

• Far cheaper: $297–$500/month

• More flexible dosing and access

• Telehealth options available

Cons:

• No official FDA oversight on quality or sterility

• Some versions contain semaglutide salts, not identical to the brand-name

• Risk of variability between pharmacies

• Must choose a reputable compounder to ensure safety

So... Which Should You Take?

Here’s how to decide:

If Cost Is Your Biggest Concern:

Compounded semaglutide is by far the most affordable. Just make sure it’s from a verified 503A or 503B pharmacy with proper sterility protocols.

If You Want an FDA-Approved Option for Weight Loss:

Wegovy is the clear winner—if you can get it and afford it.

If You're Diabetic (or Pre-Diabetic) and Want Coverage:

Ozempic may be your best route, especially if you already have an A1C diagnosis.

Bonus: What About Tirzepatide (Mounjaro, Zepbound)?

Though not semaglutide, tirzepatide (a dual GIP/GLP-1 agonist) is gaining steam and may offer even more weight loss. Zepbound is FDA-approved for obesity, and Mounjaro for type 2 diabetes.

Watch for compounded versions here too—but with similar caution about sourcing and dosage.

Final Recommendation

There is no one-size-fits-all when it comes to GLP-1 medications. Your best option depends on:

• Your health history

• Insurance or budget

• Side effect tolerance

• Your timeline and goals

No matter what you choose, work with a provider who prioritizes lab testing, safe prescribing, and ongoing support.

Get Started Safely with GOAL.MD

At GOAL.MD, we offer:

• Clinically-backed compounded GLP-1 options starting at $297/month

• Personalized onboarding with lab testing

• Weight loss plans supervised by medical experts

• Flexible treatment with coaching and education

🎯 Take the GLP-1 quiz or start your plan today →